Com provides free, accurate and independent advice on more than 24,000 prescription drugs, over-the-counter medicines natural products. OrganizedWisdom does not provide medical advice, diagnosis or treatment. Perindopril exhibits multiexponential pharmacokinetics following oral administration. As is always aceon efecte secundare the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so. However, the extent of biotransformation of perindopril to the active metabolite, perindoprilat, is reduced approximately 43 resulting in reduction in the plasma ACE inhibition curve of approximately 20 probably clinically insignificant.