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Risk C: Monitor therapy Antihistamines: Amphetamines may diminish the sedative effect of Antihistamines. Last updated on RxList: 10 29 2008 OVERDOSE Manifestations of acute overdosage with phentermine include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states. Tablets may be divided in half and dose may be given phentermine without a prescription in divided doses.